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Controlling the self-assembly and optical properties of gold nanoclusters and gold nanoparticles biomineralized with bovine serum albumin

Abstract

While the size-dependent optical properties of BSA-stabilized gold nanoclusters are well known, the time-dependent growth mechanism remains to be described. Herein, we systematically compare two synthesis methods with and without ascorbic acid, and show that tuning of BSA-stabilized gold nanoclusters (AuNCs) of different sizes can be performed without the aid of an extrinsic reducing agent and with good reproducibility. We also show that adding ascorbic acid yields larger BSA-stabilized gold nanoparticles (AuNPs), and that AuNPs can only form above a threshold gold precursor concentration. Using computed tomography, we describe how these biomineralized AuNPs show size-dependent X-ray attenuation. Growth of BSA-stabilized AuNCs and AuNPs, over a range of gold precursor concentrations, was followed with steady-state fluorescence and UV-vis spectroscopy for one week, constituting the first study of its kind. Based on our results, we propose a mechanism for BSA-stabilization of AuNCs and AuNPs that can further aid in selective growth of discrete AuNCs and AuNPs.

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Category

Academic article

Client

  • EU / 7F14057
  • Liaison Committee between the Central Norway Regional health Authority (RHA) and the Norwegian University of Science and Technology (NTNU) / 46056629
  • Liaison Committee between the Central Norway Regional health Authority (RHA) and the Norwegian University of Science and Technology (NTNU) / 46056814
  • Liaison Committee between the Central Norway Regional health Authority (RHA) and the Norwegian University of Science and Technology (NTNU) / 46052400
  • Research Council of Norway (RCN) / 197411

Language

English

Author(s)

  • Birgitte Hjelmeland McDonagh
  • Gurvinder Singh
  • Sulalit Bandyopadhyay
  • Sina Maria Lystvet
  • Joseph Anthony Ryan
  • Sondre Volden
  • Eugene Kim
  • Ioanna Sandvig
  • Axel Sandvig
  • Wilhelm R Glomm

Affiliation

  • Norwegian University of Science and Technology
  • Iona College
  • University of Cambridge
  • Umeå University
  • SINTEF Industry / Biotechnology and Nanomedicine

Year

2015

Published in

RSC Advances

ISSN

2046-2069

Publisher

Royal Society of Chemistry (RSC)

Volume

5

Issue

122

Page(s)

101101 - 101109

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