• Nanoparticles for diagnosis and therapy of cancer • Uptake and toxicity of quantum dots • Radical mechanisms of drug action • Release of encapsulated drugs from liposomes
• Miniaturized Biosensors for metabolic activities in cell cultures and tissue • New biosensing schemes based on nano materials. • Biomaterials • Bioelectronic devices
• Fate and ecotoxicity of nanomaterials in the environment, including nano-based pharmaceuticals • Methods for detection of nanoparticles in organisms and environmental matrices • Risk assessment of nanomaterials released in the environment • Microbial modification of nanomaterials
Biophysics and Medical Technology, Department of Physics, The Norwegian University of Science and Technology, NTNU, NO 7491 Trondheim
• molecular pair interactions studied at the single molecule level (dynamic force spectroscopy) • single molecule imaging • biopolymer gels /soft biomaterials
+47 73593463
Bjørn Torger Stokke
Biophysics and Medical Technology, Department of Physics, The Norwegian University of Science and Technology, NTNU, NO 7491 Trondheim
• Chitosan-based nanoparticles for non-viral gene delivery is a novel approach to selective transfection in vivo. Nanofabrication and manipulation of chitosan complexes enables tailor-making of non-viral gene delivery vehicles for therapeutic purposes. • Bioresponsive materials as signal transducers for optical detection of specific biological molecules allow biosensing in an environment requiring non-magnetic materials as in e.g. MRI. The materials being developed aim at integration of specific molecules related to the particular diagnostic situation at hand
• Smart contrast agents of nanoparticle size for MR and Ultrasound imaging • MR and ultrasound technology for improved sensitivity for MR and ultrasound contrast agents • MR and Ultrasound used for guidance and monitoring of regenerative medicine
+47 98468940
Catharina de Lange Davies
Dept. of physics, Norwegian University of Science and Technology
• to study the mechanisms of transport of macromolecules in tumour tissue; • characterise the distribution of therapeutic macromolecules in tumour tissue in situ, and correlate the distribution with physiological parameters important for the transport; • explore how physical (ultrasound and ionising radiation) and chemical (enzymes) treatments can increase the uptake and improve the distribution of macromolecules in tumours.
+47 73593688
Sabina P. Strand
NTNU, Institute for Biotechnology/NOBIPOL
• gene and siRNA delivery • biopolymer (chitosan) based delivery systems
• Lipid-based nanoparticles (liposomes) as drug delivery systems • Particle size analysis of nanoparticles • Sterile and aseptic manufacturing of drugs • Cytostatic nanomedicines
• Nanostructured biomaterial surfaces for bone engineering • Self assembly molecules in extracellular matrices and mineral deposition templating • Controlled ion implementation and activation of metal surfaces • Real-time nano imaging of surfaces of living cells
Drug formulation by use of drug-carrier systems (cyclodextrins, micelles, nanoparticles, liposomes) to obtain solubilzation of lipophilic compounds and increased bioavailability, to enhance drug stability and to obtain drug targeting.
• Selection and development of molecular agents for functional or targeted diagnostic imaging • Nanoparticles for use in biomedicine • Molecular imaging probes
RNA interference, siRNA: • Focus fields are cancer, neuroscience and heart disease • also interested in discussing possibilities in other fields of RNA interference